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IRF-3 TRANSCRIPTION FACTOR
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DeCS
Descriptor
English
:
Interferon Regulatory Factor-3
Descriptor
Spanish
:
Factor 3 Regulador del Interferón
Descriptor
Portuguese
:
Fator Regulador 3 de Interferon
Synonyms
English
:
IFN Regulatory Factor 3
IFN-Regulatory Factor 3
IRF 3 Transcription Factor
IRF-3 Transcription Factor
Interferon Regulatory Factor 3
Transcription Factor, IRF-3
Tree Number:
D12.644.360.024.302.374
D12.776.157.057.050.374
D12.776.260.504.374
D12.776.476.024.385.374
D12.776.744.562
D12.776.930.332.374
Definition
English
:
An
interferon
regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection.
PHOSPHORYLATION
of IRF-3 causes the protein to be translocated from the
CYTOPLASM
to
CELL NUCLEUS
where it binds DNA, and activates transcription.
History Note
English
:
2006(1996)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50777
Unique Identifier:
D050838
Occurrence in VHL
:
Similar:
DeCS